Theβ-cyanoalanine synthase pathway: beyond cyanide detoxification
نویسندگان
چکیده
منابع مشابه
Structure of soybean β-cyanoalanine synthase and the molecular basis for cyanide detoxification in plants.
Plants produce cyanide (CN-) during ethylene biosynthesis in the mitochondria and require β-cyanoalanine synthase (CAS) for CN- detoxification. Recent studies show that CAS is a member of the β-substituted alanine synthase (BSAS) family, which also includes the Cys biosynthesis enzyme O-acetylserine sulfhydrylase (OASS), but how the BSAS evolved distinct metabolic functions is not understood. H...
متن کاملStructure of Soybean b-Cyanoalanine Synthase and the Molecular Basis for Cyanide Detoxification in Plants
Plants produce cyanide (CN2) during ethylene biosynthesis in the mitochondria and require b-cyanoalanine synthase (CAS) for CN2 detoxification. Recent studies show that CAS is a member of the b-substituted alanine synthase (BSAS) family, which also includes the Cys biosynthesis enzyme O-acetylserine sulfhydrylase (OASS), but how the BSAS evolved distinct metabolic functions is not understood. H...
متن کاملDisulfides as cyanide antidotes: evidence for a new in vivo oxidative pathway for cyanide detoxification.
It is known that cyanide is converted to thiocyanate in the presence of the enzyme rhodanese. The enzyme is activated by sulfur transfer from an appropriate sulfur donor. The activated enzyme then binds cyanide and transfers the sulfur atom to cyanide to form thiocyanate. This project began as an exploration of the ability of disulfides to act as sulfur donors in the rhodanese-mediated detoxifi...
متن کاملBeta-cyanoalanine synthase: purification and characterization.
Beta-cyano-L-alanine synthase [L-cysteine hydrogen-sulfide-lyase (adding HCN), EC 4.4.1.9] was purified about 4000-fold from blue lupine seedlings. The enzyme was homoegeneous on gel electrophoresis and free of contamination by other pyridoxal-P-dependent lyases. The enzyme has a molecular weight of 52,000 and contains 1 mole of pyridoxal-P per mole of protein; its isoelectric point is situated...
متن کاملβ-Cyanoalanine Synthases and Their Possible Role in Pierid Host Plant Adaptation †
Cyanide is generated in larvae of the glucosinolate-specialist Pieris rapae (Lepidoptera:Pieridae) upon ingestion of plant material containing phenylalanine-derived glucosinolates as chemical defenses. As these glucosinolates were widespread within ancient Brassicales, the ability to detoxify cyanide may therefore have been essential for the host plant shift of Pierid species from Fabales to Br...
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ژورنال
عنوان ژورنال: Plant, Cell & Environment
سال: 2016
ISSN: 0140-7791
DOI: 10.1111/pce.12755